Vitamin B12 plays an important role in the formation of red blood cells, for neurological health and the production of DNA. B12 injections are available and indicated for people who cannot maintain diet-bound blood serum levels of B12. Foods rich in B12 include beef liver, clams and fortified cereal and milk. Anemia, fatigue, weakness, weight loss and loss of appetite are a few of the symptoms of a B12 deficiency.

B-12 Supplementation is good for the following conditions:

  • Lack of Energy or Fatigue
  • Weakness
  • Nervous System Health
  • Weight Loss
  • Anemia
  • Intestinal Malabsorption
  • Stomach Reduction Surgery
  • Vegetarians
  • Gastrointestinal Disorders

Orthomolecular Nutrition & Wellness offers different forms of B12, Cyanocobalamin, Hydroxocobalomin, Adenosylcobalamin and Methylcobalamin.

Deficient in vitamin B12? Trying to decide on a B12 supplement?

Cyanocobalamin, hydroxocobalamin, methylcobalamin, adenosylcobalamin, what form is best? The better question is what combination is best.

With vitamin B12 playing a vital role in the formation of healthy blood cells, energy production, nervous system, cognitive function and homocysteine regulation, it is important to supplement with the right form and combination for bioavailability and absorption.

One of the forms of B12 that is readily available and inexpensive is cyanocobalamin. However, it is synthetic and requires methylation to be utilized and eliminated from the body. The irony is that many people supplement with B12 for the express purpose of supporting methylation.

So what about hydroxocobalamin?

Hydroxocobalamin is a natural form of B12, attached to a hydroxyl group and if your body easily converts hydroxocobalamin to the active forms of B12 then this may be all you need to supplement a B12 deficiency. However, for those who need help in the conversion process or have methylation or neurological dysfunction then methylcobalamin and adenosylcobalamin will likely be required.

The European Journal of Clinical Nutrition concluded that the best way to address a B12 deficiency is the combination of the active forms MeCbl and AdCbl,


The active coenzyme forms of B12, methylcobalamin and adenosylcobalamin bypass usual mechanisms of absorption that rely on intrinsic factor.

The combination is effective in addressing both the neurological and haematopoietic pathways.

Methylcobalamin is found in the cytosol of cells and interacts with an enzyme called methionine synthase; a critical enzyme involved in DNA synthesis and may be particularly useful for individuals with impaired methylation capacity.

Adenosylcobalamin is the mitochondrial form of the B12 vitamin found in cellular tissues and interacts with an enzyme called methylmalonyl CoA mutase, a metabolic enzyme, and may be useful for those with impaired energy production.

Methylcobalamin and adenosylcobalamin have different functions thus providing a total solution for those with B12 deficiency

Methylcobalamin is an activated form of B12 which is involved in more metabolic functions than cyanocobalamin and requires no conversion by the body prior to use, unlike the Cyanocobalamin B12 that the majority of clinics offer.